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In this talk, I will review use-inspired research being conducted in the IMPACT lab at Arizona State University (http://impact.asu.edu) focused on novel secure, safe and energy-efficient (thermal-aware) adaptive solutions for cyber-physical applications of embedded and networked wireless sensors and actuators in various domains including pervasive healthcare, smart cargo containers, precision agriculture, and sustainable datacenter computing. Exemplar solutions include physiological value based key agreement scheme for body sensor networks, range-free localization using self organizing maps, and thermal-aware scheduling for data centers and biomedical sensor networks. These innovative solutions are being incorporated in software systems such as AYUSHMAN – a middleware for pervasive health monitoring and DO-COOL – thermal-aware (cool) resource management software for Datacenter Operation.